Behavioural analysis of an inherited speech and language disorder: comparison with acquired aphasia
نویسندگان
چکیده
منابع مشابه
Behavioural analysis of an inherited speech and language disorder: comparison with acquired aphasia.
Genetic speech and language disorders provide the opportunity to investigate the biological bases of language and its development. Critical to these investigations are the definition of behavioural phenotypes and an understanding of their interaction with epigenetic factors. Here, we report our investigations of the KE family, half the members of which are affected by a severe disorder of speec...
متن کاملNeural basis of an inherited speech and language disorder.
Investigation of the three-generation KE family, half of whose members are affected by a pronounced verbal dyspraxia, has led to identification of their core deficit as one involving sequential articulation and orofacial praxis. A positron emission tomography activation study revealed functional abnormalities in both cortical and subcortical motor-related areas of the frontal lobe, while quanti...
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Analyses of brain structure in genetic speech and language disorders provide an opportunity to identify neurobiological phenotypes and further elucidate the neural bases of language and its development. Here we report such investigations in a large family, known as the KE family, half the members of which are affected by a severe disorder of speech and language, which is transmitted as an autos...
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ژورنال
عنوان ژورنال: Brain
سال: 2002
ISSN: 0006-8950,1460-2156
DOI: 10.1093/brain/awf058